Micellae Delivery Systems Inc. has introduced its delivery technology, O2W, the fastest oral bioavailability-enhancing formulation.
While cannabinoids can have immense therapeutic benefits, there are several barriers to their use and formulation. O2W is a delivery system that was shown to significantly enhance the potency, bioavailability, and shelf-stability of cannabinoids while achieving an unparalleled speed of onset.
"Emulsification technologies have previously been employed in cannabinoid-based products,” said Dr. Mehdi Nouraei, University of Toronto researcher and Micellae's founder and CEO. “However, existing technologies are less than optimal and result in significant compromises, including slow onset of action, complex manufacturing, unpleasant taste, and short shelf-life. There have also been safety and environmental concerns associated with the prevalent use of polyethylene glycols. We have solved all of these issues with this unique formulation we call O2W, without compromising on speed of onset, potency, shelf-life, safety, and environmental sustainability."
O2W is a self-dispersing and fully water-dilutable Self-Microemulsifying Drug Delivery System (SMEDDS) made with food-grade excipients.
Micellae has recently completed a single-dose animal pharmacokinetic study with orally administered O2W-enhanced CBD. The study results demonstrated quick absorption, reaching maximum serum levels within 20-30 minutes compared to four hours for the control group.
"We are ecstatic about our study results,” Nouraei said. “The speed of onset is unprecedented and there is also a significant increase in bioavailability. These results also suggest dual-absorption pathways with enhanced lymphatic absorption."
Using this technology, manufacturers can not only improve existing traditional products but can also create new innovative products that were previously impossible to produce. O2W can be used to develop a wide range of products for different routes of administration. It also allows for the fine-tuning of the release profile such as speed of action, duration of action and time to reach maximum effect. O2W has a simple and cost-effective manufacturing process, using only three to four ingredients without the need for complex and energy-intensive equipment.
"The principle behind O2W is to mimic the way in which the body uses lipids to build small taxis that ferry poorly soluble molecules through tissues,” said Dr. Edgar Acosta, co-inventor and University of Toronto professor. “This contrasts with the popular glycol-based formulas that, while suitable for some applications, do not take full advantage of the way in which our bodies have evolved to absorb and use oils and fats.”
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